اثر دو ماه سبک زندگی کم تحرک بر بیان ژنی شاخص های موثر در اضافه وزن و سلامت عروق در مردان 40- 55 سال

Background: Middle-aged time is accompanied by changes in the genetic and physiological factors that contribute to obesity and cardiovascular health. Theaim of this study was investigation of the expression of Adrenergic Receptor Beta 2 (ADRB2) and Angiotensin Converting enzyme (ACE) and physiological factors in 40-55 years old men. Methods: This study was a semi-experimental research with a repeated measures design. Twenty subjects (40-55 years old) participated in the research after obtaining their consent and were prohibited from regular exercise training. Venous Blood sample were collected in two stages before and aftertwo months from the study and then BMI and VO2max were assessed. Real-time PCR was used to assess ADRB2 and ACE expression. Also, Bonfreoni methods were used for statistical analysis of the data. Results: The statistical analysis indicated that the ADRB2 expression was reduced after two months of trainig prohibition (p=0.386). The ACE expression was increased significantly after two months of training prohibition (p=0.001). BMI and Vo2max levels were not significantly changed after two months of training prohibition (p≥0.05).Conclusion: Inactive lifestyle cause increase of blood pressure and skin fat mass and reduction of vessel compliance in middle-aged men.